Sir Hugh Myddelton was a Member of Parliament from 1603 to 1628 and a successful London goldsmith. He also directed an engineering project to supply the City of London with water, through a series of canals sourced from springs near Ware, Hertfordshire. Bone's pencil drawing of this portrait of Sir Hugh is in the National Portrait Gallery.

In the 17th century, new techniques of painting enamels allowed delicate portraits resembling tiny oil paintings to be created. These enamel miniatures were first fashionable in continental Europe, but were particularly in vogue in Britain from the 1720s to 1760s. Henry Bone (1755-1834) was a successful enameller in England. As a boy, he worked in William Cookworthy's porcelain factory in Plymouth. It was there that he was introduced to the art of enamel painting. He exhibited at the Royal Academy from 1781 and became a Royal Academician in 1811. Many of his enamel portraits are copies of older full-scale paintings, including a series depicting prominent men and women from the Elizabethan period. His sons, Henry Pierce Bone (1779-1855) and William Bone Senior (active 1810-43), followed in his footsteps and became enamellers. Like his father, Henry Pierce Bone made enamel copies of paintings of historical figures.

Sir Arthur Gilbert and his wife Rosalinde formed one of the world's great decorative art collections, including silver, mosaics, enamelled portrait miniatures and gold boxes. Arthur Gilbert donated his extraordinary collection to Britain in 1996.