This image represents the earlier of the two Miraculous Draughts of Fishes in the bible. Christ, Peter and another disciple sit in Peter's boat, which is full of fish. In a second boat are three more disciples pulling in their net. The boats are low in the lake because of the large haul of fish. The fish depicted are recognisable as deep water fish, and therefore in keeping with the biblical description of this miracle.

The townscape, though not an accurate depiction, combines buildings which would have been recognisable to people in Rome at the time, including the Leonine wall, part of the medieval Vatican, and several recently constructed churches, the Torre de' Conti and the area known as the Borgo dello fornaci with its furnace, from which smoke can be seen issuing.

This print is in reverse of the cartoon from which it is derived. The so-called Raphael Cartoons, which this print reproduces, are seven full size designs for tapestries by the great Italian Renaissance artist Raphael (1483-1520). They illustrate passages from the Bible concerning the lives of Saint Peter and Saint Paul. None of them is smaller than ten feet high by thirteen feet wide. They belong to Her Majesty the Queen and have been on loan to this museum since 1865. The earliest print relating to the Raphael Cartoons dates from 1516, the year in which Raphael received final payment for the commission. It inaugurates an extraordinary case study in the history of printmaking, stretching over more than four hundred and fifty years and across a wide range of printmaking techniques.